The pathogenesis of Pisa syndrome in Parkinson's disease.
Identifieur interne : 000388 ( Main/Exploration ); précédent : 000387; suivant : 000389The pathogenesis of Pisa syndrome in Parkinson's disease.
Auteurs : Anna Castrioto [France] ; Céline Piscicelli ; Dominic Pérennou ; Paul Krack ; Bettina DebûSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease.
- etiology : Parkinson Disease, Sensation Disorders.
- pathology : Basal Ganglia, Sensation Disorders.
- physiology : Postural Balance.
- physiopathology : Musculoskeletal System.
- Animals, Humans.
Abstract
Postural abnormalities such as postural deviations affect nearly all patients with advanced Parkinson's disease and represent an important source of disability. Although their existence has long been known, their management remains a challenge as they respond poorly to medication, brain surgery, or physiotherapy. Improving management strategies will require better understanding of the mechanisms underlying such postural deformities. In this review on the pathophysiology of Pisa syndrome, we examine the data supporting the central and peripheral hypotheses that attempt to explain these lateral trunk deviations. Although the pathophysiology is very probably multifactorial, the bulk of the data supports central, rather than peripheral, hypotheses. The central hypotheses that are best supported by both animal studies and clinical data include asymmetry of basal ganglia output and abnormalities in the central integration of sensory information. Further studies are needed to elucidate the pathophysiology underlying Pisa syndrome.
DOI: 10.1002/mds.25925
PubMed: 24909134
Affiliations:
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Le document en format XML
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<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (etiology)</term>
<term>Postural Balance (physiology)</term>
<term>Sensation Disorders (etiology)</term>
<term>Sensation Disorders (pathology)</term>
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<front><div type="abstract" xml:lang="en">Postural abnormalities such as postural deviations affect nearly all patients with advanced Parkinson's disease and represent an important source of disability. Although their existence has long been known, their management remains a challenge as they respond poorly to medication, brain surgery, or physiotherapy. Improving management strategies will require better understanding of the mechanisms underlying such postural deformities. In this review on the pathophysiology of Pisa syndrome, we examine the data supporting the central and peripheral hypotheses that attempt to explain these lateral trunk deviations. Although the pathophysiology is very probably multifactorial, the bulk of the data supports central, rather than peripheral, hypotheses. The central hypotheses that are best supported by both animal studies and clinical data include asymmetry of basal ganglia output and abnormalities in the central integration of sensory information. Further studies are needed to elucidate the pathophysiology underlying Pisa syndrome.</div>
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